Production of autoreactive I region-restricted T cell hybridomas.
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چکیده
منابع مشابه
Production of autoreactive I region-restricted T cell hybridomas
We produced autoreactive T cell hybridomas that can be induced to secrete interleukin 2 by co-culture with either syngeneic splenic stimulator cells or syngeneic Ia-positive B cell-B lymphoma hybridomas. These autoreactive hybridomas arose from the fusion of pork insulin-primed lymph node T cells with the AKR thymoma BW 5147 and occurred at a higher frequency than the expected insulin-specific ...
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Five hybridoma T cell lines were prepared by fusion of second order suppressor T cells (Ts2) with the BW5147 thymoma. The culture supernates from these T cell hybrids contained a factor, TsF2, which specifically suppressed 4-hydroxy-3-nitrophenyl acetyl hapten (NP)-induced cutaneous sensitivity responses. TsF2 activity was observed when the factor was administered during the effector phases of ...
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We have examined the carrier-specific helper activity of a number of antigen-specific, I region-restricted T cell hybridomas prepared in our laboratory. The hybridomas were assayed for helper activity in the presence or absence of exogenously added nonspecific factors found in the concanavalin A-activated supernatants of normal mouse spleen cells. Of six hybridomas tested, all six could stimula...
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a b a c Katrin Schwarz , Maries van den Broek , Rita de Giuli , Wolfhart W. Seelentag , d a ,* Nilabh Shastri , Marcus Groettrup Research Department, Cantonal Hospital St. Gall, Building 09, CH-9007 St. Gallen, Switzerland b ̈ ̈ Institute of Experimental Immunology, Department of Pathology, University Hospital Zurich, CH-8091 Zurich, Switzerland Clinic for Radio-Oncology, Cantonal Hospital St. Ga...
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The development of human T cell hybridomas secreting immunoregulatory molecules has been an area of recent intense interest and investigation. Functional hybrids derived from both normal and malignant human T cells have been developed. These hybrids have been demonstrated to secrete interleukin 2 (IL-2) 1 (1), killer helper factor (2), and factors that help or suppress immunoglobulin production...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1982
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.156.2.640